PATENTED TECHNOLOGY

Microlyte® Matrix is a one-of-a-kind wound matrix that is fully-synthetic, antimicrobial, and bioresorbable.

The Microlyte Difference

Microlyte® Matrix absorbs wound fluid and forms a soft material that conforms to the wound surface and maintains a moist environment. Microlyte® Matrix is so thin that it inherently conforms to the underlying contours of a moist wound bed, providing intimate contact with the microbes on wound-bed. Antimicrobial silver in Microlyte® Matrix kills bacteria that come into contact with the product and reduces microbial colonization. This action reduces loss of silver in wound exudate and provides effective antimicrobial action at much lower silver concentrations. The dressing contains silver only to prevent or minimize microbial growth within the dressing. Reduction of bacterial bioburden may reduce microbial colonization and risks of wound infection.

Fast and Effective

Microlyte® Matrix is easy to apply. Once removed from its pouch and placed on a moist wound bed, Microlyte® Matrix immediately begins to hydrate and conform to the contours of the wound. Within seconds, the dressing has completely adhered to the wound and can be covered with the secondary dressing preferred for a given wound.

Microlyte® Matrix provides a low, but effective level of silver to the wound bed for at least 3 days to kill bacteria that come in contact with the product. This efficiency translates to less wound staining and lower residual toxicity.

Simply Peel and Place

To reapply, carefully remove the secondary cover dressing. Gently irrigate wound with sterile saline to remove necrotic tissue. It is not necessary to remove any residual Microlyte® Matrix observed during secondary cover dressing changes. Please refer to the full instructions for use.

YOUR FIRST CHOICE IN WOUND CARE

The advanced materials science employed in Microlyte® enable a one of a kind wound matrix that is fully-synthetic, antimicrobial, and bioresorbable. That’s why Microlyte® is trusted for surgical and non-surgical wounds at inpatient and outpatient facilities across the nation.

Product Microlyte® Promogran Prisma Matrix Aquacel Ag Hydrofiber Acticoat Flex
Manufacturer Imbed Biosciences 3M Convatec (BMS) Smith & Nephew
Composition Synthetic polymer Bovine collagen / regenerated cellulose Carboxymethyl cellulose Nylon fiber
Bioresorbable YES YES NO NO
Cell invasion /capillary ingrowth YES YES NO NO
Silver content (mg/100cm2) 1.2 mg 16.5 mg 12 mg 161 mg
Risk of tissue toxicity Low Minimal Minimal High
Easy to use Peel and place Need hydration Need hydration Need hydration
Painful removal NO NO YES YES
Price $$ $$ $ $

PUBLISHED RESEARCH ARTICLES

  • SW Manning, et al., Efficacy of a bioresorbable matrix in healing complex chronic wounds: An open-label prospective pilot study. Wounds, 2020. 32(11).

  • M Herron, et al., Interfacial stacks of polymeric nanofilms on soft biological surfaces that release multiple agents. ACS applied materials & interfaces, 2016. 8(40): p. 26541-26551.

  • M Herron, et al., Gallium‐loaded dissolvable microfilm constructs that provide sustained release of Ga3+ for management of biofilms. Advanced healthcare materials, 2015. 4(18): p. 2849-2859.

  • M Herron, et al., Reduction in wound bioburden using a silver‐loaded dissolvable microfilm construct. Advanced healthcare materials, 2014. 3(6): p. 916-928.

  • KM Guthrie, et al., Integration of silver nanoparticle-impregnated polyelectrolyte multilayers into murine-splinted cutaneous wound beds. Journal of Burn Care & Research, 2013. 34(6): p. e359-e367.

  • KM Guthrie, et al., Antibacterial efficacy of silver-impregnated polyelectrolyte multilayers immobilized on a biological dressing in a murine wound infection model. Annals of surgery, 2012. 256(2): p. 371.

  • A Agarwal, et al., Polymeric multilayers that localize the release of chlorhexidine from biologic wound dressings. Biomaterials, 2012. 33(28): p. 6783-6792.

  • Agarwal, A., et al., Polymeric materials for chronic wound and burn dressings, in Advanced Wound Repair Therapies. 2011, Elsevier. p. 186-208.

  • A Agarwal, et al., Polymeric multilayers that contain silver nanoparticles can be stamped onto biological tissues to provide antibacterial activity. Advanced functional materials, 2011. 21(10): p. 1863-1873.

  • A Agarwal, et al., Surfaces modified with nanometer-thick silver-impregnated polymeric films that kill bacteria but support growth of mammalian cells. Biomaterials, 2010. 31(4): p. 680-690.

PUBLISHED ABSTRACTS & CONFERENCE PROCEEDINGS

  • MJ Schurr, et al., Novel polymeric bioresorbable matrix promotes cell growth and eradicates pseudomonas biofilm. Boswick Burn and Wound Care Symposium, 2020.

  • K Trambadia, et al., Use of a novel bioresorbable wound matrix dressing with a polymeric coating containing nanoparticle silver in the treatment of diabetic foot and venous leg wounds. Symposium on Advanced Wound Healing, 2020.

  • G Pranami, et al., Microfilm polymeric matrix containing silver and gallium kills bacteria within biofilms. Wound Healing Society Annual Meeting, 2020.

  • G Pranami, et al., A novel ultrathin bioresorbable matrix containing silver and gallium for killing biofilm bacteria. Military Health System Research Symposium, 2020.

  • A Agarwal, et al., Silver impregnated nanometer thick polymer films stamped on wound beds do not impair healing. 20th Annual Meeting of Wound Healing Society (WHS), Orlando, FL, 2020.

  • Treadwell, T., The use of absorbable polyvinyl/polymeric microfilm matrix with silver in the treatment of venous ulcers: A pilot study. Symposium on Advanced Wound Healing Fall, 2019.

  • Ostler, M., Compression is key: Silver, elastic compression stockinet, and hyper-absorbent felt in direct contact with vlu granulation tissue reverses comorbid inflammation, pain and exudate that delays effective compression therapy. Symposium on Advanced Wound Healing Fall, 2019.

  • MJ Schurr, et al., Pre-clinical and clinical performance of a lightweight synthetic bioresorbable polyelectrolyte multilayer nanofilm-based antimicrobial matrix . Military Health System Research Symposium, 2019.

  • Miller, M., Use of uniquely adherent silver film (Microlyte® Matrix) to promote healing of recalcitrant diabetic neuropathic ulcers. Wild on Wounds, 2019.

  • McGuire, J., Use of a novel bioresorbable wound matrix dressing with a polymeric coating containing nanoparticle silver in the treatment of diabetic foot and venous leg wounds. Symposium on Advanced Wound Healing Fall, 2019.

  • Manning, S., Clinical evaluation of Microlyte® Ag bioresorbable matrix in complex chronic, recalcitrant wounds American College of Surgeons Clinical Congress, 2019.

  • Garoufalis, M., A new novel approach for the treatment of chronic wounds. Desert Foot 2019.

  • Chatelain, R., The efficacy of a synthetic bioresorbable antimicrobial matrix as an implantable material for at-risk surgical wounds. Symposium on Advanced Wound Healing Spring, 2019.

  • Schurr, M., The use of Microlyte® bioresorbable wound matrix as a surgical implant to prevent postoperative surgical site infection. Innovations in Wound Healing 2018, 2018.

  • Price, T., An ultrathin bioresorbable matrix with antimicrobial silver in the treatment of chronic contaminated wounds. Symposium on Advanced Wound Healing Fall, 2018.

  • Pranami, G., Microfilm bioresorbable matrix containing silver nanoparticles for cell growth and combating bacteria in deep wound tissue. American Burn Association, 2018.

  • Pranami, G., Effective antibiofilm bioresorbable microfilm matrix containing gallium and silver. Wound Healing Society, 2018.

  • Manning, S., Microlyte® Matrix stimulates wound closure in full-thickness, chronic wound in patient with multiple risk factors for non-healing. Innovations in Wound Healing 2018, 2018.

  • Crawford, E., Synthetic resorbable antibiofilm polymeric wound matrix containing gallium and silver. Innovations in Wound Healing, 2018.

  • Beatty, A., Usage of a fully synthetic bioresorbable antimicrobial matrix containing ionic and metallic silver to treat difficult-to-heal leg ulcers suspected of biofilms. Symposium on Advanced Wound Healing Fall, 2018.

  • Pranami, G., Ultrathin hydrogel dressings containing gallium ions and metallic silver for the elimination of biofilms. Wound Healing Society, 2017.

  • McAnulty, J., Use of an antimicrobial microfilm wound dressing in spontaneous wounds in animals. Wound Healing Society, 2017.

  • JL Dalsin, et al., Ultrathin microfilm dressing with silver and gallium ions disperse biofilmson biological surfaces. Symposium on Advanced Wound Care, 2017.

  • Humphrey, D., Ultrathin dissolvable antimicrobial wound dressing is safe and effective in patients with complex chronic wounds. Wound Healing Society, 2017.

  • Agarwal, A., et al., Microfilm wound contact dressing with metallic silver that conforms to wound-bed, prevents wound infection, and allows normal healing. Wound Repair and Regeneration, 2016. 24(2).

  • A Agarwal, et al., Ultrathin dissolvable wound contact dressing with metallic silver that prevents infection and allows normal healing. Wound Healing Society, 2016.

  • K Brandenburg, et al., Anti-biofilm efficacy of novel wound dressings containing tryptophan. Wound Repair and Regeneration, 2015. 23(2).

  • A Agarwal, et al., Transparent microfilm dressing with metallic silver particles prevents wound infection and allows normal wound healing. Wound Repair and Regeneration, 2014. 22(2).

  • A Agarwal, et al., Dissolvable microfilm dressing with silver-nanoparticles expedites healing of contaminated excisional wounds in mice. Wound Repair and Regeneration, 2013. 21(2).

  • KM Guthrie, et al., Antibacterial efficacy of silver-impregnated polyelectrolyte multilayers immobilized on a biological dressing in a murine wound infection model. Annals of surgery, 2012. 256(2): p. 371.

  • Agarwal, A., et al., Transferrable antibacterial nanofilms of silvernanoparticles for artificial skin. Wound Repair and Regeneration, 2012. 20(2).

  • A Agarwal, et al., Biologic dressing stamped with a chlorhexidine impregnated polymer film prevents infection and promotes normal healing in a murine wound-model. Wound Repair and Regeneration, 2012. 20(2).

  • N Shah, et al., Effect of polyelectrolyte multilayer assembly on accessibility of immobilized growth factor. Society for Biomaterials (SFB) Annual Meeting, Orlando, FL, 2011.

  • A Agarwal, et al., Integration of silver-impregnated polymeric multilayers onto biological tissues to provide antibacterial activity. Society for Biomaterials (SFB) Annual Meeting, Orlando, FL, 2011.

  • A Agarwal, et al., Antibacterial molecular coatings of silver-nanoparticles for integration in wound-beds. Wound Repair and Regeneration, 2011. 19(2).

  • H Singh, et al., Mechanical transfer of silver into wound beds utilizing nanometer-thick polymer films that do not impair wound healing. American College of Veterinary Surgeons (ACVS) Veterinary Symposium, Seattle, WA, 2010.

  • A Agarwal, et al., Nanoscopically thin polymer films with silver nanoparticles that kill bacteria with but support growth of fibroblasts. Polymeric Materials Science & Engineering Proceedings 101, 1450, 238th American Chemical Society (ACS) National Meeting, Washington, DC, 2009.

  • A Agarwal, et al., A novel, localized-release silver delivery system for chronic wounds. Wound Repair and Regeneration, 2009. 17(2).